Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.

Abstract

OBJECTIVE:

The aim of this study was to compare the effects of intravenous administration of 1.5 mg/kg and 3 mg/kg of methylprednisolone sodium succinate (MP) on pain, swelling, and trismus after third molar surgery.

STUDY DESIGN:

Twenty-six healthy patients with symmetrically impacted mandibular third molars were included in this double-blind, cross-over study. Either 1.5 mg/kg or 3 mg/kg of MP was administered by intravenous route one hour prior to the first operation. At the second operation the other dose was applied. Trismus was determined by measuring maximum interincisal opening and facial swelling was evaluated using a tape measuring method. Pain was determined using visual analogue scale and recording the number of pain pills taken.

RESULTS:

There was no statistically significant difference in trismus, facial swelling, and pain between the two groups.

CONCLUSION:

No clinical benefit of the higher dose of MP was demonstrated.

• Authors: Yakup UStün, Ozgür Erdogan, Emin Esen, Ebru Deniz Karsli
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 96 Issue 5 Pg. 535-9 (Nov 2003) ISSN: 1079-2104 [Print] United States
• PMID: 14600686 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics, Non-Narcotic
• Anti-Inflammatory Agents
• Acetaminophen
• Methylprednisolone

Topics

• Acetaminophen (therapeutic use)
• Adolescent
• Adult
• Analgesics, Non-Narcotic (therapeutic use)
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Cross-Over Studies
• Double-Blind Method
• Edema (prevention & control)
• Female
• Humans
• Male
• Methylprednisolone (administration & dosage, therapeutic use)
• Molar, Third (surgery)
• Pain Measurement
• Pain, Postoperative (prevention & control)
• Postoperative Complications (prevention & control)
• Premedication
• Prospective Studies
• Statistics, Nonparametric
• Tooth Extraction (adverse effects)
• Tooth, Impacted (surgery)
• Trismus (physiopathology, prevention & control)