Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis.

Abstract

OBJECTIVE:

To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in rats with acute edematous pancreatitis (AEP).

METHODS:

The model of AEP was established with 50 Wistar rats, and the changes of PECAM-1 expression on PMNs from the splenic vein and inferior vena cava were determined by flow cytometry.

RESULTS:

PECAM-1 expression on PMNs showed no significant difference between pancreatic microcirculation and peripheral circulation at AEP2h and AEP4h time points. From the AEP4h to the AEP8h time point, PECAM-1 expression in peripheral circulation was up-regulated, but PECAM-1 expression in pancreatic microcirculation was down-regulated. PECAM-1 expression had a significant difference between pancreatic microcirculation and peripheral circulation at the AEP8h time point (P<0.05).

CONCLUSION:

PECAM-1 expression on PMNs is in a converse way between pancreatic microcirculation and peripheral circulation in AEP.

• Authors: Hong-Kai Gao, Zong-Guang Zhou, You-Qin Chen, Fang-Hai Han, Cun Wang
• Journal: Hepatobiliary & pancreatic diseases international : HBPD INT (Hepatobiliary Pancreat Dis Int) Vol. 2 Issue 3 Pg. 463-6 (Aug 2003) ISSN: 1499-3872 [Print] Singapore
• PMID: 14599961 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Platelet Endothelial Cell Adhesion Molecule-1
• Amylases

Topics

• Acute Disease
• Amylases (blood)
• Animals
• Edema (metabolism, physiopathology)
• Female
• Male
• Microcirculation
• Neutrophils (metabolism)
• Pancreas (blood supply, metabolism)
• Pancreatitis (metabolism, physiopathology)
• Platelet Endothelial Cell Adhesion Molecule-1 (metabolism)
• Rats
• Rats, Wistar