A case of prolonged carboplatin therapy in a patient with carboplatin hypersensitivity.

Abstract

OBJECTIVES:

Platinum-containing chemotherapeutic drugs have high response rates yet are known to cause hypersensitivity reactions. Attempts have been made to rechallenge allergic patients with prolonged desensitization infusion regimens.

CASE:

A female with advanced peritoneal cancer went into remission after six cycles of paclitaxel/cisplatin. Her cancer recurred 17 months later and she was treated with paclitaxel/carboplatin. A hypersensitivity reaction to carboplatin occurred during the fourth cycle and further carboplatin was withheld. With the second recurrence carboplatin was resumed using a prolonged desensitization regimen. The patient had a third recurrence and has recently completed cycle 15 of carboplatin for a total of 56 cycles.

CONCLUSIONS:

A carboplatin desensitization regimen may allow patients with platinum-sensitive ovarian or peritoneal cancer to continue to benefit from its efficacy.

• Authors: Tara M McElroy, Vivian E von Gruenigen, Steven E Waggoner
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 91 Issue 2 Pg. 435-7 (Nov 2003) ISSN: 0090-8258 [Print] United States
• PMID: 14599880 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carboplatin
• Paclitaxel

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carboplatin (administration & dosage, adverse effects)
• Drug Administration Schedule
• Drug Hypersensitivity (etiology)
• Female
• Humans
• Middle Aged
• Paclitaxel (administration & dosage)
• Peritoneal Neoplasms (drug therapy)