Erythromycin stearate in acne vulgaris: its effect on the skin surface lipids and on the activity of purified pancreatic lipase.

To study the mechanism of action of erythromycin stearate in acne vulgaris, the composition of the skin surface lipids was analyzed before, during and after treatment (500 mg daily for 1 week, 250 mg daily for 2 months) in 17 patients. Quantitative thin-layer chromatography showed that the fatty acid fraction in the skin surface lipids decreased significantly during the treatment period. The clinical effect was good in 14 of 17 patients. Further investigations were performed on the effect of erythromycin stearate on purified pancreatic lipase. The enzyme activity was not inhibited by exposure to the drug.
AuthorsL Hellgren, J Vincent
JournalDermatologica (Dermatologica) Vol. 156 Issue 2 Pg. 105-10 ( 1978) ISSN: 0011-9075 [Print] Switzerland
PMID145975 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Fatty Acids
  • Erythromycin
  • Lipase
  • Acne Vulgaris (drug therapy)
  • Adult
  • Clinical Trials as Topic
  • Erythromycin (therapeutic use)
  • Fatty Acids (metabolism)
  • Female
  • Humans
  • Lipase
  • Lipid Metabolism
  • Male
  • Pancreas (enzymology)
  • Skin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: