Possible role of intestinal alkaline phosphatase activity in thiamine transport.

Abstract

Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++-and (Na+ + K+)-ATPase activities did not change after the administration of ethanol. These findings show that the al-Pase activity, unlike the Ca++-ATPase activity, is not related to Ca++-absorption. A possible role of al-Pase activity in the active transport of thiamine in the intestine was discussed.

• Authors: T Matsuda, A Baba, H Iwata
• Journal: Experientia (Experientia) Vol. 34 Issue 1 Pg. 18-20 (Jan 15 1978) ISSN: 0014-4754 [Print] Switzerland
• PMID: 145948 (Publication Type: Journal Article)

Chemical References

• Ethanol
• Alkaline Phosphatase
• Adenosine Triphosphatases
• Calcium
• Thiamine

Topics

• Adenosine Triphosphatases (metabolism)
• Alkaline Phosphatase (metabolism)
• Animals
• Calcium (metabolism)
• Duodenum (enzymology)
• Ethanol (pharmacology)
• Intestinal Absorption
• Male
• Rats
• Thiamine (metabolism)
• Thiamine Deficiency