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Effects of chronic ingestion of ochratoxin a on blood levels and excretion of the mycotoxin in sheep.

Abstract
Ruminants are relatively resistant to the acutely toxic effects of ochratoxin A, due to extensive degradation of ochratoxin A to its less toxic metabolite ochratoxin alpha by rumen microorganisms. However, most estimates of the degradation capacity for ochratoxin A in ruminants are based on in vitro studies. In the current study, the metabolism of ochratoxin A was investigated over a period of 29 days, feeding various doses of the mycotoxin (0, 9.5, 19.0, and 28.5 mug ochratoxin A/kg body weight) to sheep. Animals were fed diets consisting of 70% concentrates and 30% grass silage. Significant concentrations of undegraded ochratoxin A were detected in serum of sheep at all levels of ochratoxin A tested. Serum concentrations of ochratoxin A slightly accumulated with time of exposure and were linearly dependent on the administered dose of ochratoxin A. Furthermore, a constant proportion (6-8%) of the dose was excreted in the urine. The results of this study indicate that even at moderate to low levels of ochratoxin A in the diet, considerable amounts of the mycotoxin are absorbed by ruminants and may accumulate in tissues. Therefore, feeding of ochratoxin A-contaminated feedstuffs to ruminants does not seem to be a reliable means for using these feedstuffs.
AuthorsRalf Blank, Jan-Peter Rolfs, Karl-Heinz Südekum, Andrew A Frohlich, Ronald R Marquardt, Siegfried Wolffram
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 51 Issue 23 Pg. 6899-905 (Nov 05 2003) ISSN: 0021-8561 [Print] United States
PMID14582993 (Publication Type: Journal Article)
Chemical References
  • Ochratoxins
  • ochratoxin A
Topics
  • Animals
  • Diet
  • Feces (chemistry)
  • Food Contamination
  • Ochratoxins (administration & dosage, blood, pharmacokinetics)
  • Poaceae
  • Rumen (chemistry)
  • Sheep (blood)
  • Silage

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