Abstract | OBJECTIVES: PATIENTS AND METHODS: 101 patients were randomized to S and 102 to R. Time to event endpoints were compared with the Logrank test and Kaplan-Meier curves, in the intent-to-treat population (2-sided alpha=0.05). RESULTS: Baseline characteristics of both groups were comparable. There was a borderline statistically significant difference in overall survival in favour of the local field radiotherapy (R: 11 months; S: 7.2 months; p=0.0457). There was no difference in progression-free survival or time to progression. Subjective response was seen in 34.7% in the S-arm and in 33.3% in the R-arm. A biochemical response was observed in 10% and 13% of the R- and S-groups, respectively. There was no difference in treatment toxicity between the two groups. CONCLUSION: In symptomatic HRPC, pain treatment with local field radiotherapy is associated with a better overall survival compared to Strontium(89). The lower costs of local field radiotherapy also favour the use of this treatment in patients with HRPC. The reason for the apparent survival benefit of localised radiation treatment is not clear.
|
Authors | G O N Oosterhof, J T Roberts, Th M de Reijke, S A Engelholm, S Horenblas, H von der Maase, N Neymark, M Debois, L Collette |
Journal | European urology
(Eur Urol)
Vol. 44
Issue 5
Pg. 519-26
(Nov 2003)
ISSN: 0302-2838 [Print] Switzerland |
PMID | 14572748
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Chemical References |
- Biomarkers, Tumor
- Strontium Radioisotopes
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Bone Neoplasms
(secondary)
- Chi-Square Distribution
- Disease Progression
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Pain Measurement
- Prostatic Neoplasms
(pathology, radiotherapy)
- Statistics, Nonparametric
- Strontium Radioisotopes
(therapeutic use)
- Survival Rate
- Treatment Outcome
|