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Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients.

AbstractBACKGROUND:
Recently, insoluble fibre from carob pulp has been found to affect blood lipids in animals in a similar manner as soluble dietary fibre.
AIM OF THE STUDY:
To investigate whether a carob pulp preparation containing high amounts of insoluble fibre has a beneficial effect on serum cholesterol in humans.
METHODS:
Volunteers (n = 58) with hypercholesterolemia were recruited to participate in a randomised, double- blind, placebo-controlled and parallel arm clinical study with a 6 week intervention phase. All participants consumed daily both, bread (two servings) and a fruitbar (one serving) either with (n = 29) or without (n = 29) a total amount of 15 g/d of a carob pulp preparation (carob fibre). Serum concentrations of total, LDL and HDL cholesterol and triglycerides were assessed at baseline and after week 4 and 6.
RESULTS:
The consumption of carob fibre reduced LDL cholesterol by 10.5 +/- 2.2% (p = 0.010). The LDL:HDL cholesterol ratio was marginally decreased by 7.9 +/- 2.2 % in the carob fibre group compared to the placebo group (p = 0.058). Carob fibre consumption also lowered triglycerides in females by 11.3 +/- 4.5% (p = 0.030). Lipid lowering effects were more pronounced in females than in males.
CONCLUSION:
Daily consumption of food products enriched with carob fibre shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hypercholesterolemia.
AuthorsH J F Zunft, W Lüder, A Harde, B Haber, H J Graubaum, C Koebnick, J Grünwald
JournalEuropean journal of nutrition (Eur J Nutr) Vol. 42 Issue 5 Pg. 235-42 (Oct 2003) ISSN: 1436-6207 [Print] Germany
PMID14569404 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anticholesteremic Agents
  • Apolipoproteins
  • Cholesterol, LDL
  • Dietary Fiber
  • Galactans
  • Mannans
  • Plant Extracts
  • Plant Gums
  • Polysaccharides
  • Triglycerides
  • Cholesterol
  • locust bean gum
Topics
  • Adult
  • Aged
  • Analysis of Variance
  • Anticholesteremic Agents (pharmacology, therapeutic use)
  • Apolipoproteins (blood)
  • Cholesterol (blood)
  • Cholesterol, LDL (blood)
  • Dietary Fiber (administration & dosage)
  • Double-Blind Method
  • Female
  • Food, Fortified
  • Galactans
  • Humans
  • Hypercholesterolemia (blood, drug therapy, prevention & control)
  • Male
  • Mannans
  • Middle Aged
  • Phytotherapy (methods)
  • Plant Extracts (pharmacology, therapeutic use)
  • Plant Gums
  • Polysaccharides (pharmacology, therapeutic use)
  • Sex Distribution
  • Time Factors
  • Treatment Outcome
  • Triglycerides (blood)

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