Abstract | OBJECTIVE: METHODS: The tumor specimens were obtained and laser capture microdissected for analysis using the following microsatellite markers: BAT25, BAT26, BAT40, D1S2883, D2S123, D3S1611, D5S346, D7S501 and D8S25. RESULTS: All 8 patients with head and neck cancer and a colon cancer history exhibited MSI or loss of heterozygosity (LOH) at 1 or more of the markers tested. Three patients had 2 abnormal markers, 1 patient had 3 abnormal markers and 1 had 7 abnormal markers. Only 1 of the patients with a colon cancer history, all of whom had MSI, developed recurrent head and neck cancer. Of the 15 control patients, 5 had MSI or LOH and 1 had MSI or LOH at 2 markers. Three of the 5 patients with MSI or LOH had a recurrence; hence MSI and LOH at these markers were uncommon, and there was no relation between MSI and outcome in patients without a history of colon cancer. CONCLUSIONS:
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Authors | Lyon L Gleich, Jiang Wang, Jack L Gluckman, Cecilia M Fenoglio-Preiser |
Journal | ORL; journal for oto-rhino-laryngology and its related specialties
(ORL J Otorhinolaryngol Relat Spec)
2003 Jul-Aug
Vol. 65
Issue 4
Pg. 193-8
ISSN: 0301-1569 [Print] Switzerland |
PMID | 14564091
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(genetics, mortality)
- Colorectal Neoplasms
(genetics, mortality)
- DNA Mutational Analysis
- Female
- Head and Neck Neoplasms
(genetics, mortality)
- Humans
- Loss of Heterozygosity
(genetics)
- Male
- Microsatellite Repeats
(genetics)
- Middle Aged
- Polymerase Chain Reaction
- Prognosis
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