Abstract | OBJECTIVES: DESIGN AND METHODS:
Apo (a) isoforms, Lp(a) and plasma lipids were determined in 40 IDDM and 65 NIDDM patients and in 182 healthy individuals. Apo(a) isoforms were separated by 3 to 15% gradient SDS-PAGE followed by immunoblotting. RESULTS: Logistical analysis showed that: Lp(a) levels >30 mg/dL (RR = 0.25, p < 0.000001; RR = 0.18, p < 0.00002), HTA (RR = 0.212, p < 0.00001; RR = 0.30, p < 0.00001), LMW-S1 apo(a) isoform (RR = 6.86, p < 0.0131; RR = 7.04, p < 0.0057) play a significant role in aterogenecity in both groups of patients with DM ( IDDM and NIDDM). The 6.50-fold increase in risk was found in NIDDM patients with high Lp(a) levels (>30 mg/dL) and plasma total/ HDL cholesterol ratio (4.5-5.8). CONCLUSION:
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Authors | Danica D Labudovic, Katerina N Toseska, Sonja B Alabakovska, Bojana B Todorova |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 36
Issue 7
Pg. 545-51
(Oct 2003)
ISSN: 0009-9120 [Print] United States |
PMID | 14563448
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins A
- Lipoprotein(a)
- Protein Isoforms
- Cholesterol
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Topics |
- Apolipoproteins A
(blood, genetics)
- Arteriosclerosis
(blood, complications, genetics)
- Cholesterol
(blood)
- Diabetes Mellitus, Type 1
(blood, complications, genetics)
- Diabetes Mellitus, Type 2
(blood, complications, genetics)
- Disease Susceptibility
- Female
- Humans
- Lipoprotein(a)
(blood)
- Male
- Phenotype
- Protein Isoforms
(blood, genetics)
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