Abstract | UNLABELLED: MATERIALS AND METHODS: RESULTS: The most common CT features were diffuse and patchy bilateral ground-glass opacity with (n = 3) or without reticulation (n = 4) and consolidation (n = 1). These opacities showed no predilection for any particular lung zone in 6 patients but did show dependent predilection in 1 patient and upper lobe predilection in 1. Diffuse centrilobular ill-defined nodules were noted in 1 patient, which disappeared on follow-up. During the average post-treatment follow-up period of 31.0 days (range 3 to 76 days), the opacities quickly improved after treatment in 6 patients; however, in 2 patients with pre-existing interstitial pneumonitis the opacities were refractory. CONCLUSION: CT features of MTX-induced pulmonary injury were variable and included diffuse parenchymal opacification, reticular opacities, and centrilobular nodules. These opacities usually responded quickly to treatment; however, those patients with lung fibrosis at presentation may have worse prognosis.
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Authors | Hiroaki Arakawa, Masaomi Yamasaki, Yasuyuki Kurihara, Hidehiro Yamada, Yasuo Nakajima |
Journal | Journal of thoracic imaging
(J Thorac Imaging)
Vol. 18
Issue 4
Pg. 231-6
(Oct 2003)
ISSN: 0883-5993 [Print] United States |
PMID | 14561908
(Publication Type: Journal Article)
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Chemical References |
- Antirheumatic Agents
- Methotrexate
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Topics |
- Antirheumatic Agents
(adverse effects, therapeutic use)
- Arthritis, Rheumatoid
(drug therapy)
- Female
- Follow-Up Studies
- Humans
- Lung
(diagnostic imaging)
- Lupus Erythematosus, Systemic
(drug therapy)
- Male
- Methotrexate
(adverse effects, therapeutic use)
- Middle Aged
- Pneumonia
(chemically induced, diagnostic imaging)
- Retrospective Studies
- Time Factors
- Tomography, X-Ray Computed
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