Abstract | OBJECTIVE: MATERIAL AND METHODS: A randomized, single-blinded trial was performed with a convenience sample of children presenting wheezing. The children were enrolled in an emergency room and randomly assigned to one of two treatment groups: home-made spacer group or nebulizer group. Clinical scores and oxygen saturation were recorded at baseline and 15 minutes after salbutamol administration. Treatment with salbutamol (100 microg/3 kg in the spacer group, and 250 microg/3 kg in the nebulizer group) was repeated at 20-minute intervals, until the child was considered to have improved significantly, with no need of any further dose, or until three doses were delivered. Treatment cost, time spent to prepare and deliver the drug, and level of parental satisfaction with the treatment were recorded. RESULTS: Fifty-four children with age between 22 days and 11.7 years were enrolled--27 in each group. Baseline and demographic characteristics were similar for both groups. The spacer was as effective as the nebulizer in terms of clinical score and oxygen saturation. The different doses (100 microg/3 kg with the spacer, and 250 microg/3 kg with the nebulizer) were shown to be clinically equivalent. Treatment cost was significantly lower in the spacer group, as was the time to prepare and deliver the drug. Parental satisfaction was similar for both inhaler devices. CONCLUSION:
|
Authors | Liana Consuelo Santana Vilarinho, Carlos Maurício Cardeal Mendes, Leda Solano de Freitas Souza |
Journal | Jornal de pediatria
(J Pediatr (Rio J))
2003 Sep-Oct
Vol. 79
Issue 5
Pg. 403-12
ISSN: 0021-7557 [Print] Brazil |
Vernacular Title | Inalador dosimetrado com espaçador artesanal versus nebulizador no tratamento da crise de sibilância na criança. |
PMID | 14557840
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Bronchodilator Agents
- Albuterol
|
Topics |
- Albuterol
(administration & dosage)
- Bronchodilator Agents
(administration & dosage)
- Child
- Child, Preschool
- Cost-Benefit Analysis
- Equipment Design
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Metered Dose Inhalers
(economics, standards)
- Patient Satisfaction
- Respiratory Sounds
(drug effects)
- Single-Blind Method
- Status Asthmaticus
(drug therapy, economics)
|