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Acutely administered haloperidol-induced pattern changes of regional cerebral blood flow in schizophrenics. Observation from subtraction of brain imaging with single photon emission computed tomography using technetium-99m hexamethyl-propyleneamine oxime.

Abstract
Changes in regional cerebral blood flow in brain images with single photon emission computed tomography using technetium-99m hexamethyl-propyleneamine oxime before and after intramuscular injection of haloperidol (0.08 mg/kg) were studied in 5 medicated subjects in their twenties, consisting of 5 schizophrenics and 1 patient with histrionic personality disorder, by a subtraction method of brain images. The haloperidol injection induced two types of perfusion pattern change; in 2 of the schizophrenics, a relative hypoperfusion in the frontal lobes in the images prior to injection was converted to a relative hyperperfusion. In the other 3 schizophrenics and in the patient with histrionic personality disorder, the slight left hemispheric dominance was changed to a marked right hemispheric dominance. The results indicate that haloperidol affects perfusion patterns in schizophrenics.
AuthorsI Jibiki, H Matsuda, N Yamaguchi, K Kurokawa, K Hisada
JournalNeuropsychobiology (Neuropsychobiology) Vol. 25 Issue 4 Pg. 182-7 ( 1992) ISSN: 0302-282X [Print] Switzerland
PMID1454158 (Publication Type: Journal Article)
Chemical References
  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime
  • Haloperidol
Topics
  • Acute Disease
  • Adult
  • Brain (blood supply)
  • Cerebral Cortex (blood supply)
  • Dose-Response Relationship, Drug
  • Female
  • Haloperidol (administration & dosage)
  • Humans
  • Injections, Intramuscular
  • Male
  • Organotechnetium Compounds
  • Oximes
  • Psychiatric Status Rating Scales
  • Regional Blood Flow (drug effects)
  • Schizophrenia (diagnostic imaging, drug therapy)
  • Schizophrenic Psychology
  • Subtraction Technique
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon

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