Abstract |
Changes in regional cerebral blood flow in brain images with single photon emission computed tomography using technetium-99m hexamethyl-propyleneamine oxime before and after intramuscular injection of haloperidol (0.08 mg/kg) were studied in 5 medicated subjects in their twenties, consisting of 5 schizophrenics and 1 patient with histrionic personality disorder, by a subtraction method of brain images. The haloperidol injection induced two types of perfusion pattern change; in 2 of the schizophrenics, a relative hypoperfusion in the frontal lobes in the images prior to injection was converted to a relative hyperperfusion. In the other 3 schizophrenics and in the patient with histrionic personality disorder, the slight left hemispheric dominance was changed to a marked right hemispheric dominance. The results indicate that haloperidol affects perfusion patterns in schizophrenics.
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Authors | I Jibiki, H Matsuda, N Yamaguchi, K Kurokawa, K Hisada |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 25
Issue 4
Pg. 182-7
( 1992)
ISSN: 0302-282X [Print] Switzerland |
PMID | 1454158
(Publication Type: Journal Article)
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Chemical References |
- Organotechnetium Compounds
- Oximes
- Technetium Tc 99m Exametazime
- Haloperidol
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Topics |
- Acute Disease
- Adult
- Brain
(blood supply)
- Cerebral Cortex
(blood supply)
- Dose-Response Relationship, Drug
- Female
- Haloperidol
(administration & dosage)
- Humans
- Injections, Intramuscular
- Male
- Organotechnetium Compounds
- Oximes
- Psychiatric Status Rating Scales
- Regional Blood Flow
(drug effects)
- Schizophrenia
(diagnostic imaging, drug therapy)
- Schizophrenic Psychology
- Subtraction Technique
- Technetium Tc 99m Exametazime
- Tomography, Emission-Computed, Single-Photon
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