Abstract | BACKGROUND: METHODS: Ten-week-old male Imai rats were randomly assigned to those fed either a regular diet, low protein diet (LPD), or regular diet containing the adsorbent preparation, AST-120. Ten-week-old male Sprague-Dawley rats served as controls. The animals were observed for 24 weeks. Six rats were included in each group. All diets were prepared in powder form. RESULTS: The untreated 34-week-old Imai rats showed severe proteinuria, hypoalbuminemia, 50% reduction in creatinine clearance, hypercholesterolemia, hypertriglyceridemia, and elevated plasma VLDL concentration. This was associated with significant reductions in plasma post- heparin LPL activity, hepatic lipase activity, as well as adipose tissue and skeletal muscle immunodetectable LPL and VLDL receptor proteins. Protein restriction mitigated the decline in creatinine clearance, ameliorated proteinuria, hypoalbuminemia, hypertension, and hypercholesterolemia, lowered plasma VLDL, and improved plasma postheparin LPL activity, hepatic lipase activity, LPL, and VLDL receptor proteins in skeletal muscle and adipose tissue. Similar improvements were observed in all parameters with AST administration. CONCLUSION: Moderate protein restriction and use of oral adsorbent can slow progression of renal disease and, thereby, ameliorate LPL, hepatic lipase, and VLDL receptor deficiencies and the associated hyperlipidemia in rats with spontaneous FGS.
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Authors | Tadashi Sato, Kaihui Liang, Nosratola D Vaziri |
Journal | Kidney international
(Kidney Int)
Vol. 64
Issue 5
Pg. 1780-6
(Nov 2003)
ISSN: 0085-2538 [Print] United States |
PMID | 14531811
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dietary Proteins
- Oxides
- Receptors, LDL
- VLDL receptor
- Carbon
- AST 120
- Lipase
- Lipoprotein Lipase
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Topics |
- Adsorption
- Animals
- Carbon
(pharmacology)
- Diet, Protein-Restricted
- Dietary Proteins
(administration & dosage)
- Down-Regulation
(drug effects)
- Glomerulosclerosis, Focal Segmental
(blood, diet therapy, drug therapy)
- Lipase
(metabolism)
- Lipoprotein Lipase
(blood)
- Liver
(enzymology)
- Male
- Oxides
(pharmacology)
- Proteinuria
(blood, diet therapy, drug therapy)
- Rats
- Rats, Inbred Strains
- Receptors, LDL
(blood)
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