Abstract | PURPOSE: METHODS: Thirty-four consecutive patients with a clinical diagnosis of acute ITP and a platelet count below 20x10(9)/L were randomized to receive either 1 g/kg body weight (n=17; group A) or 0.3 g/kg body weight (n=17; group B) IVIG per day for 2 consecutive days (total dose 2 g/kg and 0.6 g/kg). RESULTS: Fifteen of the 17 patients (88.2%) in group A and 13 of the 17 patients (76.5%) in group B achieved a platelet count of more than 20x10(9)/L within 72 hours. The increase in platelet counts on day 2 and 3 was more pronounced in the high-dose group. Two patients in the high-dose group and four in the low-dose group were non-responders. Chronic disease occurred in three patients receiving 2 g/kg IVIG and in five patients receiving 0.6 g/kg IVIG. Side effects of IVIG administration were more common in the high-dose group. CONCLUSIONS: The present study showed that platelet counts increased more rapidly after high-dose IVIG administration within the first 72 hours, although a platelet count of more than 20x10(9)/L can be achieved also with low-dose IVIG in most children with acute ITP. For patients with very low platelet counts, doses higher than 0.6 g/kg seem, therefore, to be more effective.
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Authors | Martin Benesch, Reinhold Kerbl, Herwig Lackner, Andrea Berghold, Wolfgang Schwinger, Karin Triebl-Roth, Christian Urban |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 25
Issue 10
Pg. 797-800
(Oct 2003)
ISSN: 1077-4114 [Print] United States |
PMID | 14528103
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Immunoglobulins, Intravenous
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Topics |
- Acute Disease
- Adolescent
- Blood Platelets
(cytology, drug effects)
- Child
- Child, Preschool
- Chronic Disease
- Dose-Response Relationship, Drug
- Female
- Humans
- Immunoglobulins, Intravenous
(administration & dosage, adverse effects, therapeutic use)
- Immunotherapy
- Infant
- Male
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
(drug therapy, immunology, pathology)
- Random Allocation
- Recurrence
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