Comparative study of flavonoids in experimental models of inflammation.

Abstract

The anti-inflammatory activities of flavonols (quercetin, rutin and morin) and flavanones (hesperetin and hesperidin) were investigated in animal models of acute and chronic inflammation. Rutin was only effective in the chronic process, principally in adjuvant arthritis. On neurogenic inflammation induced by xylene, only the flavanones were effective; besides, these compounds were the most effective on subchronic process. The most important compound in reducing paw oedema induced by carrageenan was quercetin.

• Authors: Alejandra Ester Rotelli, Teresita Guardia, Américo Osvaldo Juárez, Nadir Ernesto de la Rocha, Lilian Eugenia Pelzer
• Journal: Pharmacological research (Pharmacol Res) Vol. 48 Issue 6 Pg. 601-6 (Dec 2003) ISSN: 1043-6618 [Print] Netherlands
• PMID: 14527825 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Flavonoids
• Xylenes
• Rutin
• morin
• Carrageenan
• Quercetin
• Hesperidin
• hesperetin

Topics

• Animals
• Arthritis, Experimental (prevention & control)
• Carrageenan
• Disease Models, Animal
• Ear (pathology)
• Edema (chemically induced, prevention & control)
• Flavonoids (chemistry, therapeutic use)
• Hesperidin (chemistry, therapeutic use)
• Hindlimb (pathology)
• Inflammation (chemically induced, prevention & control)
• Mice
• Molecular Structure
• Quercetin (chemistry, therapeutic use)
• Random Allocation
• Rats
• Rats, Wistar
• Rutin (chemistry, therapeutic use)
• Xylenes