Abstract | BACKGROUND: HYPOTHESIS: METHODS: Serum homocysteine levels were measured at the time of cardiac transplant evaluation in 89 consecutive patients with severe heart failure. Homocysteine levels for patients with ischemic cardiomyopathy (ICM) were compared with levels obtained in patients with nonischemic cardiomyopathy (NICM), and homocysteine levels were correlated with demographic and hemodynamic parameters as well as functional status. RESULTS: The mean plasma homocysteine level was increased (14.3 +/- 5.3 micromol/l, normal <9.0 micromol/l) and was equivalent between patients with ICM versus NICM (14.7 +/- 5.8 micromol/l vs. 13.8 +/- 4.5 micromol/l, p = 0.44). Elevated homocysteine levels were seen in a large proportion (89%) of patients and were equally common to patients with NICM (94%) and ICM (85%). Serum homocysteine levels correlated with serum creatinine (r = 0.51, p < 0.001), with a history of diabetes (p = 0.028), and with a history of peripheral vascular disease (p = 0.045). Only 6% of patients were receiving folic acid therapy at the time of transplant referral. CONCLUSION:
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Authors | Richard S Schofield, Timothy R Wessel, Tracy C Walker, Timothy S Cleeton, James A Hill, Juan M Aranda Jr |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 26
Issue 9
Pg. 407-10
(Sep 2003)
ISSN: 0160-9289 [Print] United States |
PMID | 14524595
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Hematinics
- Homocysteine
- Folic Acid
- Creatinine
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Topics |
- Biomarkers
(blood)
- Cardiomyopathies
(metabolism, therapy)
- Coronary Artery Disease
(metabolism, therapy)
- Creatinine
(blood, urine)
- Female
- Florida
- Folic Acid
(therapeutic use)
- Heart Failure
(drug therapy, metabolism, surgery)
- Heart Transplantation
- Hematinics
(therapeutic use)
- Homocysteine
(blood, drug effects)
- Humans
- Hyperhomocysteinemia
(drug therapy, metabolism, surgery)
- Male
- Middle Aged
- Oxygen Consumption
(physiology)
- Pulmonary Wedge Pressure
(physiology)
- Retrospective Studies
- Severity of Illness Index
- Statistics as Topic
- Stroke Volume
(physiology)
- Treatment Outcome
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