[Acute renal failure caused by VIP-secreting tumor].

Abstract

A 74-year-old woman had secretory diarrhea, severe metabolic acidosis, hypokalemia, hypovolemia, and acute renal failure caused by a pancreatic vasoactive intestinal polypeptide (VIP)-secreting tumor. Vipoma is a rare neuroendocrine tumor. Morbidity and mortality are related to long-standing dehydration and electrolyte and acid-base disturbance resulting in acute renal failure. Diagnosis requires the documentation of large volumes of secretory diarrhea, elevated VIP plasma levels, and the localization of the VIP-secreting tumor. Metastases are present in 50% of patients at the time of diagnosis. Treatment includes correction of volume, electrolyte, and metabolic abnormalities; CVVH during ARF; pharmacotherapy to decrease gastrointestinal secretion; and surgical resection of the vipoma.

• Authors: D Lambertini, E Bottini, E Talassi, R Tarchini, L Gaetti, A Bellomi
• Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia (G Ital Nefrol) 2003 Jul-Aug Vol. 20 Issue 4 Pg. 419-22 ISSN: 0393-5590 [Print] Italy
• Vernacular Title: Una causa rara di insufficienza renale acuta: il VIPoma.
• PMID: 14523904 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Acute Kidney Injury (etiology)
• Aged
• Female
• Humans
• Pancreatic Neoplasms (complications)
• Vipoma (complications)