Abstract |
The aim of this work was to assess the efficacy of oral N'Dribala (tuberous roots decoction of Cochlospermum planchonii Hook) treatment versus chloroquine in non-severe malaria. The study included 85 patients with uncomplicated Plasmodium falciparum infection in Banfora, Burkina Faso. Forty-six patients that received N'Dribala beverage were compared to 21 patients treated with chloroquine. All patients were monitored with clinical examination and a parasitemia control by Giemsa-stained thick films. N'Dribala appeared safe and statistically as efficient as chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria. At day 5 (D5), 57% of chloroquine-treated and 52% of N'Dribala-treated patients were cured with no detectable parasitemia (parasite density (Pd): 0) and more than 90% of whole patients were asymptomatic. N'Dribala is easily available in this country, cheap, without significant side effects and efficient with a clearly demonstrated activity on Plasmodium falciparum blood stages. This study enhances the traditional use of the Cochlospermum planchonii as alternative therapy for treatment of non-severe malaria.
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Authors | F Benoit-Vical, A Valentin, B Da, Z Dakuyo, L Descamps, M Mallié |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 89
Issue 1
Pg. 111-4
(Nov 2003)
ISSN: 0378-8741 [Print] Ireland |
PMID | 14522441
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Plant Extracts
- Chloroquine
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Topics |
- Adolescent
- Adult
- Antimalarials
(therapeutic use)
- Bixaceae
- Child
- Chloroquine
(therapeutic use)
- Female
- Humans
- Malaria, Falciparum
(drug therapy, parasitology)
- Male
- Medicine, African Traditional
- Middle Aged
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Plant Roots
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