Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew).

Abstract

Several prostanoids were investigated for a potential to induce emesis in Suncus murinus. The TP receptor agonist 11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid (U46619) induced emesis at doses as low as 3 microg/kg, i.p. but the DP receptor agonist 5-(6-Carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW245C) was approximately 1000 times less potent. The emetic action of U46619 (300 microg/kg, i.p.) was antagonized significantly by the TP receptor antagonist, vapiprost (P<0.05). EP (prostaglandin E(2), 17-phenyl-omega-trinor prostaglandin E(2), misoprostol and sulprostone), FP (prostaglandin F(2alpha) and fluprostenol) and IP (iloprost and cicaprost) receptor agonists failed to induce consistent emesis at doses up to 300-1000 microg/kg, i.p. Fluprostenol reduced nicotine (5 mg/kg, s.c.)-but not copper sulphate (120 mg/kg, intragastric)-induced emesis; the other inconsistently emetic prostanoids were inactive to modify drug-induced emesis. The results indicate an involvement of TP and possibly DP and FP receptors in the emetic reflex of S. murinus.

• Authors: Kelvin K W Kan, Robert L Jones, Man P Ngan, John A Rudd
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 477 Issue 3 Pg. 247-51 (Sep 23 2003) ISSN: 0014-2999 [Print] Netherlands
• PMID: 14522363 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biphenyl Compounds
• Heptanoic Acids
• Hydantoins
• Prostaglandins
• Prostaglandins F, Synthetic
• Receptors, Thromboxane
• fluprostenol
• Nicotine
• BW 245C
• 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
• vapiprost
• Copper Sulfate

Topics

• 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (administration & dosage, adverse effects, antagonists & inhibitors)
• Animals
• Biphenyl Compounds (administration & dosage, pharmacokinetics, therapeutic use)
• Copper Sulfate (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Female
• Heptanoic Acids (administration & dosage, pharmacokinetics, therapeutic use)
• Hydantoins (administration & dosage)
• Injections, Intraperitoneal
• Injections, Subcutaneous
• Intubation, Gastrointestinal
• Male
• Nausea (physiopathology)
• Nicotine (administration & dosage, adverse effects, antagonists & inhibitors)
• Prostaglandins (administration & dosage, adverse effects)
• Prostaglandins F, Synthetic (administration & dosage, pharmacokinetics, therapeutic use)
• Reaction Time
• Receptors, Thromboxane (drug effects, physiology)
• Shrews (physiology)
• Time Factors
• Vomiting (chemically induced, physiopathology, prevention & control)