Higher content of 18:1 trans fatty acids in subcutaneous fat of persons with coronarographically documented atherosclerosis of the coronary arteries.

Abstract

AIM:

To identify the total content of trans fatty acid (TFA) isomers and C18:1 trans isomers in subcutaneous fat samples from persons with atherosclerosis of the coronary arteries, as an indicator of dietary exposure.

METHODS:

Using capillary gas chromatography, the authors determined total content of TFA isomers and C18:1 trans isomers in the subcutaneous fat of 34 patients with ischemic heart disease who had undergone aortocoronary bypass surgery and in 46 patients with no sign of coronary disease.

RESULTS:

On average, the total TFAs in cardiac patients were 2.88 +/- 1.19% of all fatty acids, in noncardiac patients 2.56 +/- 0.89%. However, the difference is not statistically significant. The average concentration of C18:1 trans in cardiac patients (2.31 +/- 1.09%) was statistically significantly higher (p = 0.05) than in the noncardiac group (1.95 +/- 0.77%).

CONCLUSIONS:

The results obtained indicate a lower TFA load in comparison with previous studies in other countries. A higher concentration of 18:1 TFAs in the subcutaneous fat of patients with coronary disease might be an impulse to correct the dietary habits of this very high-risk population.

• Authors: P Dlouhý, E Tvrzická, B Stanková, M Vecka, A Zák, Z Straka, J Fanta, J Pachl, D Kubisová, J Rambousková, D Bílková, M Andel
• Journal: Annals of nutrition & metabolism (Ann Nutr Metab) Vol. 47 Issue 6 Pg. 302-5 ( 2003) ISSN: 0250-6807 [Print] Switzerland
• PMID: 14520026 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 S. Karger AG, Basel

Chemical References

• Dietary Fats, Unsaturated
• Trans Fatty Acids

Topics

• Adipose Tissue (chemistry)
• Case-Control Studies
• Chromatography, Gas
• Coronary Artery Disease (metabolism)
• Diet
• Dietary Fats, Unsaturated (administration & dosage)
• Female
• Humans
• Isomerism
• Male
• Middle Aged
• Trans Fatty Acids (analysis)