Abstract | OBJECTIVE: To estimate the risk of adverse birth and neonatal outcome, and miscarriage in women who used sulfamethizole during pregnancy. METHODS: The association between use of sulfamethizole and adverse birth and neonatal outcome was investigated in a case-control and a cohort study in Denmark. We used data from the Prescription Database, the Birth Registry and the Hospital Discharge Registry in North Jutland County to study any association between sulfamethizole use and first recorded miscarriage. The cohort analysis included 3484 women who received a prescription for sulfamethizole from 30 days before conception to date of delivery, and 60175 women who did not use a sulphonamide-containing drug during pregnancy or 30 days before conception. The case-control analysis included 3347 women who had a miscarriage, of whom 90 had taken sulfamethizole, and 22599 primiparous controls who had a live birth. RESULTS: CONCLUSIONS:
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Authors | Chaveewan Ratanajamit, Mette Vinther Skriver, Mette Nørgaard, Peter Jepsen, Henrik Carl Schønheyder, Henrik Toft Sørensen |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 52
Issue 5
Pg. 837-41
(Nov 2003)
ISSN: 0305-7453 [Print] England |
PMID | 14519675
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Sulfamethizole
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Topics |
- Abnormalities, Drug-Induced
(etiology)
- Abortion, Spontaneous
(etiology)
- Anti-Infective Agents
(adverse effects)
- Case-Control Studies
- Denmark
- Female
- Humans
- Infant, Low Birth Weight
- Infant, Newborn
- Infant, Premature
- Jaundice, Neonatal
- Pregnancy
- Pregnancy Outcome
- Registries
- Sulfamethizole
(adverse effects)
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