Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer: a single center randomized study.

Abstract

AIM:

In this study we determined the protective role of amifostine against the side effects of the combination of paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC).

PATIENTS AND METHODS:

Chemo-naive patients with NSCLC were eligible. Thirty-eight patients were randomized to receive paclitaxel 175 mg/m2 and carboplatin AUC = 6 with amifostine 910 mg/m2 (group B) or chemotherapy alone (group A). The occurrences of hematologic, neurologic, cardiologic toxicities, and ototoxicity were evaluated.

RESULTS:

All patients completed the six scheduled cycles of therapy. A total of 114 cycles of chemotherapy was given in both groups. Neutropenia grade 3-4 was observed in 11 cycles (9.6%) in group A and 19 cycles (16.6%) in group B (p = 0.16). Paresthesia grade 1 or 2 was observed in 18 of 19 patients of group A and in 8 of 19 patients of group B, following the sixth cycle of chemotherapy (p = 0.018). Two patients of group B and nine patients of group A suffered from sensory motor impairment grade 2 (p = 0.029). There was no clinical evidence in any patient for deterioration in cardiac function. Asymptomatic and transient sinus bradycardia or ventricular premature beats developed in four patients. None of the patients reported vertigo, tinnitus, or hearing loss.

CONCLUSION:

The addition of the amifostine to the combination of paclitaxel and carboplatin may prevent or reduce the incidence of neurotoxicity in the treatment of NSCLC. Amifostine does not appear to have a preventive role in neutropenia.

• Authors: Ozkan Kanat, Turkkan Evrensel, Ibrahim Baran, Hakan Coskun, Mehmet Zarifoglu, Omer Faruk Turan, Ender Kurt, Mutlu Demiray, Guzin Gonullu, Osman Manavoglu
• Journal: Medical oncology (Northwood, London, England) (Med Oncol) Vol. 20 Issue 3 Pg. 237-45 ( 2003) ISSN: 1357-0560 [Print] United States
• PMID: 14514973 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Protective Agents
• Carboplatin
• Amifostine
• Paclitaxel

Topics

• Amifostine (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carboplatin (administration & dosage, adverse effects)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Cytoprotection
• Female
• Heart Diseases (chemically induced, prevention & control)
• Hematologic Diseases (chemically induced, prevention & control)
• Humans
• Lung Neoplasms (drug therapy, pathology)
• Male
• Middle Aged
• Nervous System Diseases (chemically induced, prevention & control)
• Paclitaxel (administration & dosage, adverse effects)
• Prospective Studies
• Protective Agents (administration & dosage, therapeutic use)