Abstract |
A prospective, randomized, pilot study comparing 500 cGy (group A) versus 1,000 cGy (group B) radiation treatment for the prevention of heterotopic bone in a consecutive group of high-risk patients undergoing total hip arthroplasty was performed. Treatment was initiated within ninety-six hours and given in equal, divided doses: 2 doses for group A and 5 doses for group B. No statistically significant difference was found in the demographics between the 2 groups. At follow-up evaluation, the distribution of heterotopic bone according to the Brooker classification was: group A, 9 class 0, 17 class 1, one class 2, and 2 class 3. Group B: 17 class 0, 10 class 1, 2 class 2, and one class 3. This difference was not statistically significant (P=.086). Only 3 cases were considered treatment failures, for a success rate of 93% in group A and 97% in group B. As a result of this pilot study, 500 cGy radiation treatment appears to be effective in the prevention of clinically significant heterotopic ossification after total hip arthroplasty.
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Authors | Douglas E Padgett, Keith G Holley, Marilyn Cummings, Aaron G Rosenberg, Dale R Sumner, Dean Conterato, Jorge O Galante |
Journal | The Journal of arthroplasty
(J Arthroplasty)
Vol. 18
Issue 6
Pg. 677-86
(Sep 2003)
ISSN: 0883-5403 [Print] United States |
PMID | 14513439
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Topics |
- Adult
- Aged
- Arthroplasty, Replacement, Hip
(adverse effects)
- Chi-Square Distribution
- Female
- Humans
- Male
- Middle Aged
- Ossification, Heterotopic
(diagnostic imaging, etiology, prevention & control, radiotherapy)
- Pilot Projects
- Prospective Studies
- Radiography
- Radiotherapy Dosage
- Risk Factors
- Statistics, Nonparametric
- Treatment Outcome
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