Abstract |
Poor outcomes following OLT for HCV disease have been associated with several host, viral, and non-host/non-viral factors. As is evident from the literature, there is confounding data in favor of and against these factors in the pathogenesis of severe recurrent HCV. Nevertheless, from a viral perspective, the patient most likely to achieve a good outcome following OLT is someone with low-level (< or = 10(9) copies/mL) HCV RNA viremia both pre- and post-OLT and a genotype other than lb. In terms of host factors, the patients with best outcomes are: whites, men, less than 49 years of age, receiving a donor liver less than 40 years of age, not coinfected with CMV, and have low HAI or histologic activity indices during the early stage of follow-up. Host recipient immune homology may or may not be a major factor in outcomes. A non-host, non-viral factor favoring less severe recurrence of HCV is a shorter warm ischemia time. Finally, features that may influence outcomes over which there is no control include: recipient age, recipient gender, and donor age (in the case of cadaveric donors). Unfortunately, the best-case scenario is uncommon.
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Authors | Steven B Porter, K Rajender Reddy |
Journal | Clinics in liver disease
(Clin Liver Dis)
Vol. 7
Issue 3
Pg. 603-14
(Aug 2003)
ISSN: 1089-3261 [Print] United States |
PMID | 14509529
(Publication Type: Journal Article, Review)
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Topics |
- Age Factors
- Female
- Genotype
- Graft Rejection
(virology)
- Hepacivirus
(growth & development)
- Hepatitis C, Chronic
(pathology, surgery, virology)
- Humans
- Immunosuppression Therapy
(methods)
- Liver Transplantation
- Male
- Organ Preservation
(methods)
- Recurrence
- Sex Factors
- Viremia
(pathology, virology)
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