Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?

Dopamine replacement therapy (DRT) is the most effective treatment for Parkinson's disease (PD); it provides substantial benefit for most patients, extends independence, and increases survival. A few patients with PD, however, take increasing quantities of medication far beyond those required to treat their motor disabilities. These patients demand rapid drug escalation and continue to request more DRT despite the emergence of increasingly severe drug-induced motor complications and harmful behavioural consequences. In this article we detail the features of compulsive DRT-seeking and intake in PD, in relation to theories of compulsive drug use.
AuthorsAndrew D Lawrence, Andrew H Evans, Andrew J Lees
JournalThe Lancet. Neurology (Lancet Neurol) Vol. 2 Issue 10 Pg. 595-604 (Oct 2003) ISSN: 1474-4422 [Print] England
PMID14505581 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Dopamine
  • Disease Management
  • Dopamine (adverse effects, therapeutic use)
  • Humans
  • Models, Biological
  • Movement Disorders (etiology, therapy)
  • Parkinson Disease (physiopathology, therapy)
  • Reward
  • Substance-Related Disorders

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