Stage-specific expression of breast cancer-specific gene gamma-synuclein.

Abstract

Gamma-synuclein (SNCG), also referred as breast cancer-specific gene 1, is the third member of a neuronal protein family synuclein. SNCG is highly expressed in human-infiltrating breast carcinomas but not expressed in normal or benign breast tissues. To evaluate the clinical relevance of SNCG expression in breast cancer progression and its correlation with clinical parameters, we analyzed SNCG expression in 79 clinical breast specimens from primary breast cancer, hyperplasia, and fibroadenoma patients by reverse transcription-PCR. The status of estrogen receptor, progesterone receptor, proliferating cell nuclear antigen, and C-erBb2 was also analyzed by immunohistochemistry. Overall SNCG mRNA expression was detectable in 38.8% of breast cancers. However, 79% of stage III/IV breast cancers were positive for SNCG expression, whereas only 15% of stage I/II breast cancers were positive for SNCG expression. In contrast, the expression of SNCG was undetectable in all benign breast lesions. The expression of SNCG was strongly correlated to the stage of breast cancer (P=0.000). This study suggests that the expression of SNCG is stage specific for breast cancer. SNCG is expected to be a useful marker for breast cancer progression and a potential target for breast cancer treatment.

• Authors: Kejin Wu, Ziyi Weng, Qinghua Tao, Gufa Lin, Xiangru Wu, Huiqin Qian, Yichu Zhang, Xiaoyan Ding, Yangfu Jiang, Yuenian Eric Shi
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 12 Issue 9 Pg. 920-5 (Sep 2003) ISSN: 1055-9965 [Print] United States
• PMID: 14504205 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Nerve Tissue Proteins
• Oncogene Proteins v-erbB
• Proliferating Cell Nuclear Antigen
• Receptors, Estrogen
• Receptors, Progesterone
• Synucleins
• gamma-Synuclein

Topics

• Breast Neoplasms (genetics, metabolism, pathology)
• Carcinoma, Ductal, Breast (genetics, metabolism, pathology)
• Female
• Fibroadenoma (genetics, metabolism, pathology)
• Gene Expression
• Humans
• Hyperplasia
• Middle Aged
• Neoplasm Staging
• Nerve Tissue Proteins (genetics, metabolism)
• Oncogene Proteins v-erbB (genetics, metabolism)
• Oncogenes
• Proliferating Cell Nuclear Antigen (genetics, metabolism)
• Receptors, Estrogen (genetics, metabolism)
• Receptors, Progesterone (genetics, metabolism)
• Synucleins
• gamma-Synuclein