Abstract |
Examinations of 1599 residents of a polyinvasion focus at a seaside province Ha Nam Nin, Vietnam, have revealed clonorchiasis in approximately 13.9% of the examinees; in subjects aged over 30 this value was 29.3%. Factors conducive to a lower incidence of clonorchiasis were detected, among them a moderate intensity of the invasion: the mean arithmetic was 1419 +/- 306 eggs/g, the mean geometric 673 egg/g, as shown by the Kato-Kats' technique. Analysis of five therapeutic schemes used in clonorchiasis, making use of chloxilin, medamin or praziquantel, has demonstrated a low efficacy of all of them. Praziquantel therapy in a daily dose of 25 mg/kg for 2 days was found the most effective (52%), being conducive to a reduction of the invasion intensity by at least 90%. Such therapy was associated with a high incidence of side effects (91.2%), this ruling out a higher dosage.
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Authors | T L Kieu, A M Bronshteĭn, T P Sabgaĭda |
Journal | Meditsinskaia parazitologiia i parazitarnye bolezni
(Med Parazitol (Mosk))
1992 Jul-Aug
Issue 4
Pg. 7-11
ISSN: 0025-8326 [Print] Russia (Federation) |
Vernacular Title | Klonorkhoz v SRV. Soobshchenie 2. Kliniko-parazitologicheskoe obsledovanie ochaga i opyt lecheniia prazikvantelem. |
PMID | 1435590
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Antiplatyhelmintic Agents
- Benzimidazoles
- Carbamates
- Xylenes
- Praziquantel
- hexachloro-4-xylene
- carbendazim
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Topics |
- Adult
- Animals
- Antiplatyhelmintic Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Carbamates
- Clonorchiasis
(drug therapy, parasitology)
- Clonorchis sinensis
- Disease Reservoirs
- Drug Evaluation
- Feces
(parasitology)
- Humans
- Parasite Egg Count
- Praziquantel
(adverse effects, therapeutic use)
- Rural Population
- Vietnam
- Xylenes
(therapeutic use)
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