REGULATION OF XANTHINE DEHYDROGENASE IN CHICK LIVER. EFFECT OF STARVATION AND OF ADMINISTRATION OF PURINES AND PURINE NUCLEOSIDES.

Abstract	1. The xanthine-dehydrogenase activity of chick liver, expressed per mg. of nitrogen, is increased during starvation. 2. Administration of inosine and possibly of adenine has a comparable effect on the xanthine dehydrogenase, and also induces an elevation of the total quantity of enzyme. Hypoxanthine, xanthine, guanine, xanthosine, guanosine and adenosine are ineffective. Cortisone is equally ineffective. 3. The administration of puromycin abolishes the effect of inosine and reduces that of starvation. It is concluded that inosine induces an increased synthesis of xanthine dehydrogenase, whereas during starvation the enzyme is spared with respect to other liver proteins. 4. The hypothesis is formulated that chick-liver xanthine dehydrogenase is an adaptive enzyme, its activity being regulated by inosine or by one of its metabolites.
Authors	F STIRPE, E DELLACORTE
Journal	The Biochemical journal (Biochem J) Vol. 94 Pg. 309-13 (Feb 1965) ISSN: 0264-6021 [Print] England
PMID	14348191 (Publication Type: Journal Article)
Chemical References	Hypoxanthines Nucleosides Purine Nucleosides Purines Ribonucleosides Xanthines Guanosine Puromycin Inosine Guanine xanthosine Xanthine Dehydrogenase Xanthine Oxidase Adenine Adenosine Cortisone purine
Topics	Adenine Adenosine Animals Chickens Cortisone Guanine Guanosine Hypoxanthines Inosine Liver (enzymology) Nucleosides Pharmacology Poultry Purine Nucleosides Purines Puromycin Research Ribonucleosides Spectrophotometry Starvation Xanthine Dehydrogenase Xanthine Oxidase Xanthines

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