[Acid-base balance disorder in various diseases--diabetes mellitus].

Metabolic acidosis is the serious acid-base balance disorder complicated in diabetes mellitus. The pathogenesis and treatment of various type of metabolic acidosis (Keto-acidosis, lactic acidosis, hyperchloremic acidosis and type IV renal tubular acidosis) are discussed. Metabolic acidosis in the diabetic patient is associated with an increased anion-gap caused by the presence of organic anion (beta-hydroxybutyrate, acetoacetate, and lactate). The rise in anion-gap usually equals the fall in plasma bicarbonate. With appropriate therapy, progressive decline in the anion-gap is one of the best indications of successful treatment. If hyperchloremic acidosis is established, appropriate infusion of hypochloremic rehydration fluid may be useful.
AuthorsT Yoshimi
JournalNihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 50 Issue 9 Pg. 2206-12 (Sep 1992) ISSN: 0047-1852 [Print] JAPAN
PMID1434013 (Publication Type: English Abstract, Journal Article, Review)
  • Acidosis, Lactic (etiology)
  • Diabetes Complications
  • Diabetic Ketoacidosis (metabolism)
  • Humans

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