HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Clinical studies on imipenem/cilastatin sodium in the early therapy of preterm premature rupture of the membrane or threatened abortion and premature delivery].

Abstract
The efficacy and safety of early therapy with imipenem/cilastatin sodium (IPM/CS) were studied in patients who had chorioamnionitis with preterm PROM or threatened abortion and premature delivery. The following results were obtained. 1. The clinical efficacy of IPM/CS administered by intravenous drip infusion at daily dosages of 1 to 2 g as concurrent treatment with antiuteronics (ritodrine hydrochloride or terbutaline sulfate) was studied in patients with threatened abortion and premature delivery in the 11th to 34th week of pregnancy (n = 9), or premature PROM in the 23rd to 36th week (n = 9). 2. Response to IPM/CS were good in all of the patients with threatened abortion and premature delivery. Latent periods were prolonged for more than 7 days in 44.4% (4/9) of the patients with preterm PROM. 3. Changes in elastase appeared to be significant as those in CRP for inflammatory markers. 4. These findings combined with our previous results indicate that treatment of preterm PROM before the 32nd of pregnancy prolongs the latent period.
AuthorsT Chimura
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 45 Issue 8 Pg. 1023-8 (Aug 1992) ISSN: 0368-2781 [Print] Japan
PMID1433891 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cilastatin
  • Imipenem
Topics
  • Abortion, Threatened (drug therapy, etiology)
  • Adult
  • Chorioamnionitis (complications, drug therapy)
  • Cilastatin (administration & dosage, therapeutic use)
  • Drug Therapy, Combination (administration & dosage, therapeutic use)
  • Female
  • Fetal Membranes, Premature Rupture (drug therapy, etiology)
  • Humans
  • Imipenem (administration & dosage, therapeutic use)
  • Infusions, Intravenous
  • Obstetric Labor, Premature (drug therapy, etiology)
  • Pregnancy
  • Pregnancy Complications, Infectious (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: