Comparison of acute and steady-state conditions of gallopamil therapy in stable angina pectoris.

Abstract

We studied 12 patients with stable effort angina in a randomized, double-blind, cross-over and placebo-controlled trial to compare the different antianginal efficacy of "acute" and "chronic" (after reaching a steady-state level) gallopamil therapy. Efficacy was assessed using treadmill exercise testing (Bruce protocol) after a 50 mg single-dose and at the end of a nine-dose course of 50 mg of gallopamil (given three times a day). Three daily exercise tests were performed the first, second, fifth and eighth day of the study protocol at 8, 12 and 16 h. Four hours after a single-dose of gallopamil 50 mg both angina-free exercise time and time to 1 mm ST segment depression increased by a mean value of 78 s (p < 0.003) and 53 s (p < 0.03), respectively, with respect to placebo values. Under steady-state conditions exercise time and time to 1 mm ST segment depression increased by a mean value of 59 s (p < 0.009) and 46 s (p < 0.015), respectively, 4 h after the last dose. The duration of the anti-ischemic effects was no longer present after 8 h for both treatment schedules. Furthermore no significant differences were observed on parameters of ischemia after a single dose as compared to "chronic" therapy. The results of this study reveal that, in accordance with the pharmacodynamic properties of the drug, the anti-ischemic efficacy of 50 mg of gallopamil remains for approximately 4 h. Reaching a steady-state condition does not imply a prolongation of the anti-ischemic effect.

• Authors: F G Vilchez, T Villarroel, J Ruano Calvo, J A Vazquez de Prada, R Martin-Duran, J M San Jose, A Pajaron
• Journal: International journal of cardiology (Int J Cardiol) Vol. 37 Issue 1 Pg. 91-9 (Oct 1992) ISSN: 0167-5273 [Print] Netherlands
• PMID: 1428294 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gallopamil

Topics

• Angina Pectoris (blood, drug therapy)
• Blood Pressure (drug effects)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Administration Schedule
• Electrocardiography (drug effects)
• Exercise Test (drug effects)
• Female
• Gallopamil (pharmacokinetics, therapeutic use)
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged