Abstract |
apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when challenged with a high fat Western-type diet, these animals have plasma cholesterol levels of 1821 mg/dl compared with 132 mg/dl in controls. This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries. apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Authors | A S Plump, J D Smith, T Hayek, K Aalto-Setälä, A Walsh, J G Verstuyft, E M Rubin, J L Breslow |
Journal | Cell
(Cell)
Vol. 71
Issue 2
Pg. 343-53
(Oct 16 1992)
ISSN: 0092-8674 [Print] United States |
PMID | 1423598
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins E
- Lipoproteins
- Lipoproteins, IDL
- Lipoproteins, VLDL
- Cholesterol
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Topics |
- Animals
- Aorta
(pathology)
- Apolipoproteins E
(deficiency)
- Arteriosclerosis
(genetics, pathology)
- Cholesterol
(blood)
- Coronary Vessels
(pathology)
- Disease Models, Animal
- Hypercholesterolemia
(genetics, pathology)
- Lipoproteins
(blood)
- Lipoproteins, IDL
- Lipoproteins, VLDL
(blood)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Pulmonary Artery
(pathology)
- Stem Cells
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