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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.

Abstract
apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when challenged with a high fat Western-type diet, these animals have plasma cholesterol levels of 1821 mg/dl compared with 132 mg/dl in controls. This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries. apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
AuthorsA S Plump, J D Smith, T Hayek, K Aalto-Setälä, A Walsh, J G Verstuyft, E M Rubin, J L Breslow
JournalCell (Cell) Vol. 71 Issue 2 Pg. 343-53 (Oct 16 1992) ISSN: 0092-8674 [Print] United States
PMID1423598 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Apolipoproteins E
  • Lipoproteins
  • Lipoproteins, IDL
  • Lipoproteins, VLDL
  • Cholesterol
Topics
  • Animals
  • Aorta (pathology)
  • Apolipoproteins E (deficiency)
  • Arteriosclerosis (genetics, pathology)
  • Cholesterol (blood)
  • Coronary Vessels (pathology)
  • Disease Models, Animal
  • Hypercholesterolemia (genetics, pathology)
  • Lipoproteins (blood)
  • Lipoproteins, IDL
  • Lipoproteins, VLDL (blood)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Pulmonary Artery (pathology)
  • Stem Cells

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