Abstract | OBJECTIVE: METHODS: 76 eight week old Sprague-Dawley rats weighing 180 to 200 g were used for the studies. Using videodensitometry total collagen volume fraction was separated into the various components for the left and right ventricles in the following experimental models: renovascular hypertension occurring following unilateral renal ischaemia; continuous aldosterone administration via osmotic minipumps with either high (AL) or low (ALLO) sodium diet; renovascular hypertension and AL after pretreatment and continuous treatment with either 20 or 200 mg.kg-1.d-1 subcutaneously of the competitive aldosterone receptor antagonist spironolactone. All groups were compared to age and sex matched controls. RESULTS: CONCLUSIONS:
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Authors | C G Brilla, K T Weber |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 26
Issue 7
Pg. 671-7
(Jul 1992)
ISSN: 0008-6363 [Print] England |
PMID | 1423431
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Sodium, Dietary
- Angiotensin II
- Spironolactone
- Aldosterone
- Collagen
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Topics |
- Aldosterone
(blood, pharmacology)
- Angiotensin II
(blood)
- Animals
- Cardiomegaly
(blood, metabolism, pathology)
- Collagen
(metabolism)
- Disease Models, Animal
- Fibrosis
- Hypertension, Renovascular
(blood, metabolism, pathology)
- Male
- Myocardium
(metabolism, pathology)
- Rats
- Rats, Sprague-Dawley
- Sodium, Dietary
(administration & dosage)
- Spironolactone
(pharmacology)
|