Abstract | OBJECTIVE: METHODS: We treated 53 patients who presented with chronic PFPS in 1 knee, according to 1 of the 3 protocols, in a prospective, randomized, double-blind study. Basic conservative treatment consisted of a 6-week program of quadriceps muscle exercise, elimination of symptom-producing activities, and oral doses of nonsteroidal antiinflammatory drugs. Physiologic saline served as placebo for injection. During the 6-week treatment period, 5 injections were given 1 week apart. Along with measurements of quadriceps strength, standardized subjective, functional, and clinical assessments were performed at presentation, after 6 weeks of treatment, and after 6 months. RESULTS: Results at 6 months indicated that IA injections of GAGPS or saline did not result in significant improvement beyond the good results achieved by the basic conservative treatment alone. More than two-thirds of the patients in each group experienced complete recovery. CONCLUSION: Neither the GAGPS injections nor the physiologic saline injections are more effective than conservative therapy in the treatment of chronic PFPS. Restoration of normal quadriceps muscle function to the affected knee seems to be crucial in treating PFPS.
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Authors | P Kannus, A Natri, S Niittymäki, M Järvinen |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 35
Issue 9
Pg. 1053-61
(Sep 1992)
ISSN: 0004-3591 [Print] United States |
PMID | 1418021
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycosaminoglycans
- A73025
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Topics |
- Adolescent
- Adult
- Chi-Square Distribution
- Chronic Disease
- Combined Modality Therapy
- Double-Blind Method
- Exercise Therapy
- Female
- Glycosaminoglycans
(administration & dosage, therapeutic use)
- Humans
- Injections, Intra-Articular
- Joint Diseases
(drug therapy, therapy)
- Knee Joint
- Leg
- Male
- Muscles
- Pain
(drug therapy)
- Pain Management
- Prospective Studies
- Syndrome
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