Remission of scleroderma during chemotherapy for lymphoma.

Abstract

Temporary remission of scleroderma during the successful treatment of an associated malignant lymphoma by chemotherapy is reported in a patient with systemic sclerosis and mixed connective tissue disease. There is a well established relation between malignant disease and polymyositis/dermatomyositis but no overall association with systemic sclerosis or mixed connective tissue disease. Reports of the coexistence of malignancy and systemic sclerosis, however, emphasise a close temporal relation in their occurrence. A review of published work has identified several postulated mechanisms for this relation which may explain the response to chemotherapy.

• Authors: M Comer, A R Harvey
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 51 Issue 8 Pg. 998-1000 (Aug 1992) ISSN: 0003-4967 [Print] England
• PMID: 1417129 (Publication Type: Case Reports, Journal Article)

Chemical References

• Procarbazine
• Mechlorethamine
• Vincristine
• Prednisone

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Female
• Hodgkin Disease (complications, drug therapy)
• Humans
• Mechlorethamine (administration & dosage)
• Prednisone (administration & dosage)
• Procarbazine (administration & dosage)
• Recurrence
• Scleroderma, Systemic (complications, drug therapy)
• Vincristine (administration & dosage)