Abstract | OBJECTIVE: DESIGN: Randomized, block design. SETTING: Animal research facility. SUBJECTS: Fifty-six mixed-breed newborn piglets aged 1 to 4 days and weighing 1.8 to 2.7 kg. INTERVENTIONS: After instillation of a 2.2-mL/kg solution of 25% meconium, 56 piglets were randomized to receive treatment with (1) a conventional positive-pressure infant ventilator, (2) the Bunnell Life Pulse high-frequency jet ventilator, (3) the Bird model VDR high-frequency flow interruptor, or (4) the Infant Star high-frequency flow interruptor. We adjusted ventilator settings to maintain partial pressures of arterial oxygen (PaO2) of 80 to 120 cm H2O and partial pressures of arterial carbon dioxide (PaCO2) of 30 to 50 cm H2O during the 6 hours of ventilation. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: The finding of less severe pathologic alterations with various types of high-frequency ventilators justifies further investigations into the management of the meconium aspiration syndrome with these devices.
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Authors | T E Wiswell, N H Foster, M V Slayter, W E Hachey |
Journal | American journal of diseases of children (1960)
(Am J Dis Child)
Vol. 146
Issue 11
Pg. 1287-93
(Nov 1992)
ISSN: 0002-922X [Print] United States |
PMID | 1415063
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Topics |
- Animals
- Animals, Newborn
- Blood Gas Analysis
- Disease Models, Animal
- High-Frequency Jet Ventilation
- High-Frequency Ventilation
- Humans
- Infant, Newborn
- Intermittent Positive-Pressure Ventilation
- Meconium Aspiration Syndrome
(blood, pathology, therapy)
- Random Allocation
- Respiration, Artificial
- Swine
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