[Change in the opioid peptide level in the heart and blood plasma during acute myocardia ischemia complicated by ventricular fibrillation].

Abstract

After occlusion of the anterior descending coronary artery content of opioid peptides was increased 2-3-fold in blood plasma of all the rats with and without ventricular fibrillation. Content of Leu-enkephalin was decreased in ischemic and non-ischemic regions of myocardium under conditions of ventricular fibrillation. At the same time, concentration of Met-enkephalin in myocardium was increased in the acute ischemia independently on the effect of fibrillation. Synthetic enzyme-resistant derivative of Leu-enkephalin, administered before acute myocardial ischemia, prevented a decrease in the ventricular fibrillation threshold caused by the occlusion. Alteration of the Leu-enkephalin content in heart tissue appears to be importance in pathogenesis of ventricular fibrillation developed after acute myocardial ischemia.

• Authors: L N Maslov, Iu B Lishmanov
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1992 Mar-Apr Vol. 38 Issue 2 Pg. 21-3 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Izmenenie urovnia opioidnykh peptidov v serdtse i plazme krovi pri ostroĭ ishemii miokarda, oslozhnennoĭ fibrilliatsieĭ zheludochkov.
• PMID: 1413622 (Publication Type: English Abstract, Journal Article)

Chemical References

• Enkephalin, Methionine
• Enkephalin, Leucine

Topics

• Acute Disease
• Animals
• Enkephalin, Leucine (blood, metabolism)
• Enkephalin, Methionine (blood, metabolism)
• Male
• Myocardial Ischemia (blood, complications, metabolism)
• Myocardium (chemistry)
• Rats
• Rats, Wistar
• Ventricular Fibrillation (complications)