Relative efficacy of melarsen oxide compared with mel Cy (Cymelarsan) when used in combination with difluoromethylornithine in the treatment of trypanosomiasis of the central nervous system.

Abstract

A comparison was made between the efficacy of mel Cy (Cymelarsan) and melarsen oxide to cure central nervous system trypanosomiasis in a chronic Trypanosoma brucei mouse model. Combination treatment with difluoromethylornithine and arsenical was used and it was found that there was only a marginal advantage in using the water-soluble mel Cy in terms of the numbers of mice cured.

• Authors: F W Jennings
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) 1992 May-Jun Vol. 86 Issue 3 Pg. 257-8 ISSN: 0035-9203 [Print] England
• PMID: 1412647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Arsenicals
• Trypanocidal Agents
• melarsen
• melaminylthioarsenate
• Eflornithine

Topics

• Animals
• Arsenicals (therapeutic use)
• Central Nervous System Diseases (drug therapy)
• Drug Therapy, Combination
• Eflornithine (therapeutic use)
• Mice
• Models, Biological
• Trypanocidal Agents (therapeutic use)
• Trypanosomiasis, African (drug therapy)