Influence of leukemia P388 on plasma concentration-time profiles of bendamustine in B6D2F1 mice.

Abstract

It was the aim of this study to investigate whether leukemia P388 being an important murine transplantation tumor may alter the plasma concentration-time profiles of the alkylating antineoplastic agent bendamustine (1) in mice. In an advanced tumor stage the rapid decline of 1 plasma levels was found to be retarded in tumor-bearing in comparison to tumor-free animals both after i.v. and p.o. drug administration. These changes cannot be explained by the neoplasia-related depression of drug metabolism whereas the 1-containing ascitic fluid may be a possible reason for the prolonged drug levels in plasma. After p.o. administration of 1, the bioavailability of the drug was found to be increased in the leukemia-bearing animals.

• Authors: R Amlacher, H Weber, R Preiss, H Hoffmann
• Journal: Die Pharmazie (Pharmazie) Vol. 47 Issue 5 Pg. 378-81 (May 1992) ISSN: 0031-7144 [Print] Germany
• PMID: 1409829 (Publication Type: Journal Article)

Chemical References

• Nitrogen Mustard Compounds
• Bendamustine Hydrochloride

Topics

• Administration, Oral
• Animals
• Bendamustine Hydrochloride
• Female
• Injections, Intravenous
• Leukemia P388 (metabolism)
• Mice
• Mice, Inbred Strains
• Nitrogen Mustard Compounds (pharmacokinetics)