[Detection of polymeric IgA antibody to herpes simplex virus by pretreatment of sera with Streptococcus pyogenes--its application to diagnosis of primary infection].

In 17 patients of genital herpes virus infections, herpes simplex virus (HSV)-specific IgA antibody responses were analyzed using an enzyme-linked immunosorbent assay (ELISA) and the absorption of sera with Streptococcus pyogenes, AW43 and AR1, which bind monomeric IgA (m-IgA) and IgG antibodies, respectively. The ratio of polymeric IgA (p-IgA) to total IgA was calculated from the formula, the p-IgA index = IgA activity after absorption/IgA activity before absorption. In early-convalescent-phase sera from primary cases, the p-IgA indices were 0.5-0.9, whereas in recurrent or provoked cases, they were lower than 0.2. There results indicate that the p-IgA index may be useful for rapid and simple differentiation of primary from non-primary HSV infections.
AuthorsM Hashido, T Kawana, S Inouye
JournalKansenshoŐĄgaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 66 Issue 2 Pg. 225-31 (Feb 1992) ISSN: 0387-5911 [Print] JAPAN
PMID1402085 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibodies, Viral
  • Immunoglobulin A
  • Polymers
  • Antibodies, Viral (analysis)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Herpes Genitalis (diagnosis)
  • Humans
  • Immunoglobulin A (analysis)
  • Polymers (analysis)
  • Recurrence
  • Serologic Tests (methods)
  • Streptococcus pyogenes (immunology)

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