Abstract | BACKGROUND: OBJECTIVE: Our purpose was to determine DC phenotype in psoriatic compared with normal epidermis with respect to these molecules. METHODS: RESULTS: In psoriatic compared with normal skin, decreased numbers of DCs expressed CD1a (p less than 0.05), whereas increased numbers of DCs expressed class II major histocompatibility antigens (p less than 0.05). In normal skin positive staining for CD18 was not observed, whereas in psoriasis both CD1a+ and CD1a- DCs expressed beta 2-integrins, LFA-1 (CD11a/CD18), and gp 150/95 (CD11c/CD18). DCs in atopic dermatitis and lichen planus were also found to express beta 2-integrins. Neither MAC 1 (CD11b/CD18) nor ICAM-1 was observed on DCs. CONCLUSION: These data are consistent with either migration of dendritic antigen-presenting cells into the epidermis or in situ cytokine modulation of Langerhans cell phenotype in inflamed skin. Furthermore, they indicate that epidermal DCs in psoriasis and other cutaneous inflammatory diseases express molecules that are known to be crucial for Langerhans cell-driven T-cell activation in vitro.
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Authors | J M McGregor, J N Barker, E L Ross, D M MacDonald |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 27
Issue 3
Pg. 383-8
(Sep 1992)
ISSN: 0190-9622 [Print] United States |
PMID | 1401271
(Publication Type: Journal Article)
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Chemical References |
- Cell Adhesion Molecules
- Lymphocyte Function-Associated Antigen-1
- Receptors, Leukocyte-Adhesion
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Topics |
- Cell Adhesion Molecules
- Dendritic Cells
(immunology)
- Dermatitis, Atopic
(immunology, pathology)
- Epidermis
(immunology)
- Humans
- Immunohistochemistry
- Langerhans Cells
(immunology)
- Lichen Planus
(immunology, pathology)
- Lymphocyte Function-Associated Antigen-1
(immunology)
- Phenotype
- Psoriasis
(immunology, pathology)
- Receptors, Leukocyte-Adhesion
(immunology)
- Up-Regulation
(immunology)
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