HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Labor characteristics of uncomplicated prolonged pregnancies after induction with intracervical prostaglandin E2 gel versus intravenous oxytocin.

Abstract
Labor characteristics after intracervical application of 0.5 mg prostaglandin (PG) E2 gel (n = 83) versus intravenous administration of oxytocin (n = 82) for labor induction were investigated in uncomplicated prolonged pregnancies with unripe cervix. The induction to delivery time as well as the total oxytocin dose were significantly reduced in the PGE2 group (p < 0.001). Cesarean sections, instrumental deliveries and fetal distress had the same frequency, but the failures of trial were significantly higher in the oxytocin group than in the PGE2 group (20.7 vs. 6%, p < 0.01). Twenty-four percent of women needed a second PGE2 dose, and almost half of the women in the PGE2 group experienced 'spontaneous' labor. More neonates in the oxytocin group had 5-min Apgar scores < 7 (p < 0.05). Intracervical PGE2 gel application is superior to intravenous oxytocin in terms of shortening the induction-delivery interval and increasing the frequency of successful vaginal delivery. In addition, it is safe for mother and fetus.
AuthorsI Papageorgiou, C Tsionou, D Minaretzis, S Michalas, D Aravantinos
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 34 Issue 2 Pg. 92-6 ( 1992) ISSN: 0378-7346 [Print] Switzerland
PMID1398272 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Oxytocin
  • Dinoprostone
Topics
  • Administration, Intravaginal
  • Adult
  • Delivery, Obstetric (methods, standards)
  • Dinoprostone (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Infusions, Intravenous
  • Labor, Induced (methods, standards)
  • Oxytocin (administration & dosage, therapeutic use)
  • Parity
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy, Prolonged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: