HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.

Abstract
The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.
AuthorsJ W McDonald, D D Schoepp
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 215 Issue 2-3 Pg. 353-4 (May 14 1992) ISSN: 0014-2999 [Print] Netherlands
PMID1383003 (Publication Type: Journal Article)
Chemical References
  • Receptors, Amino Acid
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • Ibotenic Acid
  • N-Methylaspartate
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Topics
  • Animals
  • Brain (drug effects)
  • Cycloleucine (analogs & derivatives, toxicity)
  • Drug Synergism
  • Ibotenic Acid (analogs & derivatives, toxicity)
  • In Vitro Techniques
  • N-Methylaspartate (toxicity)
  • Rats
  • Rats, Inbred Strains
  • Receptors, Amino Acid (drug effects)
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: