Abstract |
The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate ( NMDA)-, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid ( AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.
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Authors | J W McDonald, D D Schoepp |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 215
Issue 2-3
Pg. 353-4
(May 14 1992)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 1383003
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Amino Acid
- Cycloleucine
- 1-amino-1,3-dicarboxycyclopentane
- Ibotenic Acid
- N-Methylaspartate
- alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Topics |
- Animals
- Brain
(drug effects)
- Cycloleucine
(analogs & derivatives, toxicity)
- Drug Synergism
- Ibotenic Acid
(analogs & derivatives, toxicity)
- In Vitro Techniques
- N-Methylaspartate
(toxicity)
- Rats
- Rats, Inbred Strains
- Receptors, Amino Acid
(drug effects)
- alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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