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Teicoplanin--domiciliary use in surgical infections.

Abstract
This is an ongoing study designed to evaluate the role of teicoplanin in the therapy of sternal wound infections following cardiac surgery caused by Gram-positive microorganisms. Intravenous teicoplanin therapy is begun in the hospital, but once the patients return home it is given as a single intramuscular dose of 400 mg/day. Only a limited number of patients have been recruited so far, but in these, the clinical success rate and the bacteriological elimination rate are 85%. Only one patient had to be withdrawn from the study due to intolerable side-effects. These preliminary results suggest that teicoplanin is suitable for the therapy of chest wound infections following cardiac surgery; a major part of the course can be administered at home in a single daily intramuscular injection. This novel therapy regimen is expected to reduce considerably the hospital costs involved in the therapy of sternal wound infections.
AuthorsE Rubinstein
JournalThe European journal of surgery. Supplement. : = Acta chirurgica. Supplement (Eur J Surg Suppl) Issue 567 Pg. 27-9 ( 1992) ISSN: 1102-416X [Print] England
PMID1381638 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Glycopeptides
  • Teicoplanin
Topics
  • Ambulatory Care
  • Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
  • Coronary Disease (surgery)
  • Glycopeptides (administration & dosage, adverse effects, therapeutic use)
  • Humans
  • Mediastinitis (drug therapy)
  • Staphylococcal Infections (drug therapy)
  • Staphylococcus epidermidis
  • Surgical Wound Infection (drug therapy)
  • Teicoplanin

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