Abstract |
We studied the relationship of serum insulin-like growth factor-I ( IGF-I), IGF-II, the IGF-binding proteins IGFBP-1, IGFBP-2, and IGFBP-3, and GH-binding protein (GHBP; which is postulated to be derived from the extracellular portion of the GH receptor) in normal volunteers and patients with anorexia nervosa before and after a refeeding program. Serum GHBP, IGF-I, and IGFBP-3 were all significantly decreased in low weight patients with anorexia nervosa and returned to nearly normal levels with refeeding. Fasting serum GH and serum IGFBP-1 and IGFBP-2 were significantly increased in low weight patients with anorexia nervosa and also returned to nearly normal levels with refeeding. Serum IGF-II was 27% lower in the low weight group than in normal subjects, but this difference was not statistically significant. Both serum IGF-I and IGF-II were positively correlated with serum IGFBP-3 and negatively correlated with serum IGFBP-1 and IGFBP-2. These data are consistent with the hypothesis that nutritional deprivation alters the GH-IGF axis by down-regulation of the GH receptor or its postreceptor mechanisms, and that this effect is reversible with refeeding.
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Authors | D R Counts, H Gwirtsman, L M Carlsson, M Lesem, G B Cutler Jr |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 75
Issue 3
Pg. 762-7
(Sep 1992)
ISSN: 0021-972X [Print] United States |
PMID | 1381372
(Publication Type: Journal Article)
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Chemical References |
- Carrier Proteins
- Insulin-Like Growth Factor Binding Proteins
- Somatomedins
- Growth Hormone
- somatotropin-binding protein
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Topics |
- Adult
- Anorexia Nervosa
(blood, pathology, therapy)
- Body Mass Index
- Carrier Proteins
(blood)
- Eating
- Female
- Growth Hormone
(blood)
- Humans
- Insulin-Like Growth Factor Binding Proteins
- Somatomedins
(metabolism)
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