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The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.

Abstract
We studied the relationship of serum insulin-like growth factor-I (IGF-I), IGF-II, the IGF-binding proteins IGFBP-1, IGFBP-2, and IGFBP-3, and GH-binding protein (GHBP; which is postulated to be derived from the extracellular portion of the GH receptor) in normal volunteers and patients with anorexia nervosa before and after a refeeding program. Serum GHBP, IGF-I, and IGFBP-3 were all significantly decreased in low weight patients with anorexia nervosa and returned to nearly normal levels with refeeding. Fasting serum GH and serum IGFBP-1 and IGFBP-2 were significantly increased in low weight patients with anorexia nervosa and also returned to nearly normal levels with refeeding. Serum IGF-II was 27% lower in the low weight group than in normal subjects, but this difference was not statistically significant. Both serum IGF-I and IGF-II were positively correlated with serum IGFBP-3 and negatively correlated with serum IGFBP-1 and IGFBP-2. These data are consistent with the hypothesis that nutritional deprivation alters the GH-IGF axis by down-regulation of the GH receptor or its postreceptor mechanisms, and that this effect is reversible with refeeding.
AuthorsD R Counts, H Gwirtsman, L M Carlsson, M Lesem, G B Cutler Jr
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 75 Issue 3 Pg. 762-7 (Sep 1992) ISSN: 0021-972X [Print] United States
PMID1381372 (Publication Type: Journal Article)
Chemical References
  • Carrier Proteins
  • Insulin-Like Growth Factor Binding Proteins
  • Somatomedins
  • Growth Hormone
  • somatotropin-binding protein
Topics
  • Adult
  • Anorexia Nervosa (blood, pathology, therapy)
  • Body Mass Index
  • Carrier Proteins (blood)
  • Eating
  • Female
  • Growth Hormone (blood)
  • Humans
  • Insulin-Like Growth Factor Binding Proteins
  • Somatomedins (metabolism)

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