WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

Abstract	Data from several studies suggest that tachykinins may play an important role in the pathophysiology of airway diseases, especially asthma. Our aim is to discover tachykinin antagonists which exhibit therapeutically useful anti-asthmatic activity. In our search for activities inhibiting the binding of [3H]substance P to guinea-pig lung membrane preparations, we have found that the fermentation product, WS9326A, isolated from Streptomyces violaceusniger, is a potent tachykinin receptor antagonist.
Authors	K Hayashi, M Hashimoto, N Shigematsu, M Nishikawa, M Ezaki, M Yamashita, S Kiyoto, M Okuhara, M Kohsaka, H Imanaka
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 45 Issue 7 Pg. 1055-63 (Jul 1992) ISSN: 0021-8820 [Print] England
PMID	1381343 (Publication Type: Journal Article)
Chemical References	Lactones Peptides, Cyclic Tachykinins WS 9326A FK 224 Substance P
Topics	Animals Asthma (drug therapy) Fermentation Guinea Pigs In Vitro Techniques Lactones (chemistry, isolation & purification, pharmacology) Microscopy, Electron, Scanning Peptides, Cyclic (chemistry, isolation & purification, pharmacology) Streptomyces (chemistry) Substance P (antagonists & inhibitors, metabolism) Tachykinins (antagonists & inhibitors)

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