Abstract |
The percentages of minor adult hemoglobin (% Hb A2) in hemolysates and G gamma-globin chain (%G gamma) in fetal Hb (Hb F) of 15 individuals with elevated Hb F levels (2.0-11%) among 11,000 healthy Japanese adults were examined. Most of them might be carriers for the determinants of hereditary persistence of fetal hemoglobin. Subjects with less than 1.3% Hb A2, some of whom might be also carriers for delta-thalassemia determinants, had high G gamma values (54-70%). Those homozygous for a subhaplotype [+-----] 5' to the delta-globin gene had low to mid G gamma values (7-49%), while those homozygous for [-++-++] possessed high G gamma values (60-85%), but varied Hb F values (3.1-11%). Those heterozygous for the presence of the XmnI site 5' to (-158 bp to the cap site of) the G gamma-globin gene had mid to high G gamma values (53-65%). Factors for the high or low G gamma-globin gene expression in the Japanese adult with elevated Hb F level should be highly associated with a subhaplotype [-++-++] or [+-----], respectively.
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Authors | K Shimizu, H Keino |
Journal | Human heredity
(Hum Hered)
Vol. 42
Issue 4
Pg. 222-30
( 1992)
ISSN: 0001-5652 [Print] Switzerland |
PMID | 1380945
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Globins
- Hemoglobin A2
- Fetal Hemoglobin
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Topics |
- Adult
- Fetal Hemoglobin
(genetics, metabolism)
- Globins
(genetics)
- Haplotypes
(genetics)
- Hemoglobin A2
(genetics)
- Hemoglobinopathies
(genetics)
- Humans
- Japan
(epidemiology)
- Multigene Family
(genetics)
- Polymorphism, Genetic
(genetics)
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