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%Hb A2, %Hb F, %G gamma values and the haplotypes in the beta-globin gene cluster in Japanese adults with elevated Hb F.

Abstract
The percentages of minor adult hemoglobin (%Hb A2) in hemolysates and G gamma-globin chain (%G gamma) in fetal Hb (Hb F) of 15 individuals with elevated Hb F levels (2.0-11%) among 11,000 healthy Japanese adults were examined. Most of them might be carriers for the determinants of hereditary persistence of fetal hemoglobin. Subjects with less than 1.3% Hb A2, some of whom might be also carriers for delta-thalassemia determinants, had high G gamma values (54-70%). Those homozygous for a subhaplotype [+-----] 5' to the delta-globin gene had low to mid G gamma values (7-49%), while those homozygous for [-++-++] possessed high G gamma values (60-85%), but varied Hb F values (3.1-11%). Those heterozygous for the presence of the XmnI site 5' to (-158 bp to the cap site of) the G gamma-globin gene had mid to high G gamma values (53-65%). Factors for the high or low G gamma-globin gene expression in the Japanese adult with elevated Hb F level should be highly associated with a subhaplotype [-++-++] or [+-----], respectively.
AuthorsK Shimizu, H Keino
JournalHuman heredity (Hum Hered) Vol. 42 Issue 4 Pg. 222-30 ( 1992) ISSN: 0001-5652 [Print] Switzerland
PMID1380945 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Globins
  • Hemoglobin A2
  • Fetal Hemoglobin
Topics
  • Adult
  • Fetal Hemoglobin (genetics, metabolism)
  • Globins (genetics)
  • Haplotypes (genetics)
  • Hemoglobin A2 (genetics)
  • Hemoglobinopathies (genetics)
  • Humans
  • Japan (epidemiology)
  • Multigene Family (genetics)
  • Polymorphism, Genetic (genetics)

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