Abstract |
We retrospectively reviewed 29 cases of ventral abdominal wall defects to evaluate the usefulness of amniotic fluid markers in the prenatal assessment of those disorders. Amniotic fluid alpha-fetoprotein (AF-AFP) values were available in 17 cases diagnosed prior to 22 weeks' gestation and acetylcholinesterase (AF-ACE) values, in 21 cases. All 7 fetuses with a gastroschisis had an elevated AF-AFP, while only 2 of the 10 fetuses with an omphalocele had elevated values (P = .002). ACE was present in 80% of the cases of gastroschisis versus 27.3% of the cases of omphalocele (P = .03). With equivocal sonographic findings, a normal AF-AFP and negative AF-ACE may be more compatible with an omphalocele.
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Authors | J M Tucker, C G Brumfield, R O Davis, C L Winkler, L R Boots, N E Krassikoff, J C Hauth |
Journal | The Journal of reproductive medicine
(J Reprod Med)
Vol. 37
Issue 5
Pg. 445-8
(May 1992)
ISSN: 0024-7758 [Print] United States |
PMID | 1380559
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- alpha-Fetoproteins
- Acetylcholinesterase
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Topics |
- Acetylcholinesterase
(chemistry)
- Alabama
(epidemiology)
- Amniotic Fluid
(chemistry)
- Biomarkers
(chemistry)
- Diagnosis, Differential
- Female
- Hernia, Umbilical
(diagnosis, epidemiology)
- Hernia, Ventral
(congenital, diagnosis, epidemiology)
- Hospitals, University
- Humans
- Infant, Newborn
- Pregnancy
- Pregnancy Outcome
- Prenatal Diagnosis
(methods, standards)
- Retrospective Studies
- Sensitivity and Specificity
- Ultrasonography, Prenatal
(standards)
- alpha-Fetoproteins
(chemistry)
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