Abstract |
Recent studies have shown that hepatitis C virus antibodies are present in a large proportion of patients with autoimmune hepatitis type 2. We have studied 83 patients with liver/kidney microsome antibody-positive type 1 hepatitis. Hepatitis C virus antibodies were sought in every case by second-generation tests (hepatitis C virus enzyme-linked immunosorbent assay and recombinant immunoblot assay). Hepatitis C virus RNA sequences were sought in 22 patients (12 with recombinant immunoblot assay-positive results and 10 with recombinant immunoblot assay-negative results) by means of polymerase chain reaction and by use of primers located in the 5' noncoding region. Sixty-four patients (77%) had positive results for hepatitis C virus antibodies in the enzyme-linked immunosorbent assay test, and 41 (49.3%) were confirmed by recombinant immunoblot assay. Hepatitis C virus RNA sequences were found in all the recombinant immunoblot assay-positive patients but in none of the 10 who were recombinant immunoblot assay-negative. The recombinant immunoblot assay-negative patients were younger than those who were positive (13 +/- 11 vs. 50 +/- 11 years) and had higher gamma-globulin levels and liver/kidney microsome antibody-positive type 1 titers (61% had a titer of 1:1,000 or more, vs. only 17% of the recombinant immunoblot assay-positive patients).(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | F Lunel, N Abuaf, L Frangeul, P Grippon, M Perrin, Y Le Coz, D Valla, E Borotto, A M Yamamoto, J M Huraux |
Journal | Hepatology (Baltimore, Md.)
(Hepatology)
Vol. 16
Issue 3
Pg. 630-6
(Sep 1992)
ISSN: 0270-9139 [Print] United States |
PMID | 1380479
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Bretylium Compounds
- Hepatitis Antibodies
- Hepatitis C Antibodies
- anti-liver kidney microsome antibody
- iodobenzyltrimethylammonium
- Alanine Transaminase
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Topics |
- Adolescent
- Adult
- Aged
- Alanine Transaminase
(blood)
- Autoantibodies
(blood)
- Autoimmune Diseases
(blood, classification, immunology)
- Bretylium Compounds
- Child
- Child, Preschool
- Enzyme-Linked Immunosorbent Assay
- Female
- Hepatitis Antibodies
(blood)
- Hepatitis C
(blood, classification, immunology)
- Hepatitis C Antibodies
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
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